A phase 2 study evaluating the efficacy and safety of a novel, proprietary, nano-formulated, lower dose oral diclofenac.

作者: Garen Manvelian , Stephen Daniels , Allan Gibofsky

DOI: 10.1111/J.1526-4637.2012.01479.X

关键词:

摘要: … nano-formulated diclofenac 35 mg or 18 mg, celecoxib 400 … for nano-formulated diclofenac 35 mg and 18 mg, celecoxib, … (P < 0.001, nano-formulated diclofenac compared with placebo)…

参考文章(21)
Piotr Głuszko, Aneta Bielińska, Non-steroidal anti-inflammatory drugs and the risk of cardiovascular diseases: are we going to see the revival of cyclooxygenase-2 selective inhibitors? Polskie Archiwum Medycyny Wewnetrznej-polish Archives of Internal Medicine. ,vol. 119, pp. 231- 235 ,(2009) , 10.20452/PAMW.662
SC Lewis, MJS Langman, Joan‐Ramon Laporte, John NS Matthews, Michael D Rawlins, Bengt‐Erik Wiholm, None, Dose–response relationships between individual nonaspirin nonsteroidal anti-inflammatory drugs (NANSAIDs) and serious upper gastrointestinal bleeding: a meta-analysis based on individual patient data British Journal of Clinical Pharmacology. ,vol. 54, pp. 320- 326 ,(2002) , 10.1046/J.1365-2125.2002.01636.X
Mark Kowalski, Douglas G Stoker, Charles Bon, Keith A Moore, Stephen E Boesing, A pharmacokinetic analysis of diclofenac potassium soft-gelatin capsule in patients after bunionectomy. American Journal of Therapeutics. ,vol. 17, pp. 460- 468 ,(2010) , 10.1097/MJT.0B013E3181AA3EDA
Dennis S. Riff, Steven Duckor, Ira Gottlieb, Eric Diamond, Scott Soulier, Gary Raymond, Stephen E. Boesing, Diclofenac potassium liquid-filled soft gelatin capsules in the management of patients with postbunionectomy pain: A phase III, multicenter, randomized, double-blind, placebo-controlled study conducted over 5 days Clinical Therapeutics. ,vol. 31, pp. 2072- 2085 ,(2009) , 10.1016/J.CLINTHERA.2009.09.011
Elliot V. Hersh, Lawrence M. Levin, Dennis Adamson, Steven Christensen, Theodore A. Kiersch, Robert Noveck, Gene Watson, James A. Lyon, Dose-ranging analgesic study of prosorb® diclofenac potassium in postsurgical dental pain Clinical Therapeutics. ,vol. 26, pp. 1215- 1227 ,(2004) , 10.1016/S0149-2918(04)80033-X
Stephen E Daniels, Douglas R Baum, Francis Clark, Michael H Golf, Mark E McDonnell, Stephen E Boesing, None, Diclofenac potassium liquid-filled soft gelatin capsules for the treatment of postbunionectomy pain. Current Medical Research and Opinion. ,vol. 26, pp. 2375- 2384 ,(2010) , 10.1185/03007995.2010.515478
R. Bakshi, G. Frenkel, G. Dietlein, B. Meurer-Witt, B. Schneider, U. Sinterhauf, A Placebo‐Controlled Comparative Evaluation of Diclofenac Dispersible Versus Ibuprofen in Postoperative Pain After Third Molar Surgery The Journal of Clinical Pharmacology. ,vol. 34, pp. 225- 230 ,(1994) , 10.1002/J.1552-4604.1994.TB03990.X
Andrew T. Chan, JoAnn E. Manson, Christine M. Albert, Claudia U. Chae, Kathryn M. Rexrode, Gary C. Curhan, Eric B. Rimm, Walter C. Willett, Charles S. Fuchs, Nonsteroidal Antiinflammatory Drugs, Acetaminophen, and the Risk of Cardiovascular Events Circulation. ,vol. 113, pp. 1578- 1587 ,(2006) , 10.1161/CIRCULATIONAHA.105.595793
Ingrid Chantler, Duncan Mitchell, Andrea Fuller, The effect of three cyclo-oxygenase inhibitors on intensity of primary dysmenorrheic pain. The Clinical Journal of Pain. ,vol. 24, pp. 39- 44 ,(2008) , 10.1097/AJP.0B013E318156DAFC