Drug--drug interaction between NSAIDS and low-dose aspirin: a focus on cardiovascular and GI toxicity

摘要: Introduction: The aging of the population in US and other countries means that a large number people will likely take NSAIDs for relief pain low-dose aspirin (LD-ASA) cardioprotection. However, cardioprotective value LD-ASA can be compromised patients who concomitantly, because some competitively bind to critical amino-acid residues on cyclooxygenase (COX) enzymes interfere with mechanism antiplatelet activity LD-ASA.Areas covered: A review literature was conducted provide an overview current issues surrounding concomitant use LD-ASA, explore potential mechanisms this drug–drug interaction consider future treatment options may mitigate risk associated their use.Expert opinion: offer effective most common forms pain, such as low back musculoskeletal arthritis, postsurgical headache, acute syndr...