Pharmakologie der Nichtopioidanalgetika

作者: J. Schneider , R. Kreutz , J. Bolbrinker

DOI: 10.1007/S00482-018-0339-X

关键词:

摘要: Aufgrund hoher Verordnungszahlen und der haufigen Selbstmedikation mit rezeptfrei erhaltlichen Nichtopioidanalgetika ist die Berucksichtigung dieser Arzneistoffgruppe bei Beurteilung gesamten Medikation eines individuellen Patienten von Bedeutung. Dieser Beitrag beschreibt grundlegende pharmakologische Kenngrosen charakteristische Nebenwirkungen Analgetika. Eine weitere Einteilung Nichtopioide kann anhand zusatzlich zur Analgesie zu erreichenden Effekte erfolgen. antipyretische antiphlogistische Wirkung weisen dabei Acetylsalicylsaure in analgetischer Dosierung, traditionellen nichtsteroidalen Analgetika/Antiphlogistika sowie Coxibe auf. Metamizol Paracetamol sind Analgetika antipyretischer Wirkung, wobei spasmolytisch wirkt. Rein analgetisch wirken Capsaicin das intrathekal applizierende Ziconotid.

参考文章(47)
Garry G Graham, Michael J Davies, Richard O Day, Anthoulla Mohamudally, Kieran F Scott, None, The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings Inflammopharmacology. ,vol. 21, pp. 201- 232 ,(2013) , 10.1007/S10787-013-0172-X
Lihong Chen, Guangrui Yang, Tilo Grosser, Prostanoids and inflammatory pain. Prostaglandins & Other Lipid Mediators. ,vol. 104, pp. 58- 66 ,(2013) , 10.1016/J.PROSTAGLANDINS.2012.08.006
T Hohlfeld, K Schrör, Inhibition of Antiplatelet Effects of Aspirin by Nonopioid Analgesics Clinical Pharmacology & Therapeutics. ,vol. 97, pp. 131- 134 ,(2015) , 10.1002/CPT.21
Burkhard Hinz, Olga Cheremina, Jouri Bachmakov, Bertold Renner, Oliver Zolk, Martin F. Fromm, Kay Brune, Dipyrone elicits substantial inhibition of peripheral cyclooxygenases in humans: new insights into the pharmacology of an old analgesic The FASEB Journal. ,vol. 21, pp. 2343- 2351 ,(2007) , 10.1096/FJ.06-8061COM
Fernanda Crunfli, Fabiana C Vilela, Alexandre Giusti-Paiva, Cannabinoid CB1 receptors mediate the effects of dipyrone Clinical and Experimental Pharmacology and Physiology. ,vol. 42, pp. 246- 255 ,(2015) , 10.1111/1440-1681.12347
Srinivas Nalamachu, Joseph V Pergolizzi, Robert B Raffa, Dhanunjaya R Lakkireddy, Robert Taylor, Drug--drug interaction between NSAIDS and low-dose aspirin: a focus on cardiovascular and GI toxicity Expert Opinion on Drug Safety. ,vol. 13, pp. 903- 917 ,(2014) , 10.1517/14740338.2014.924924
Paola Patrignani, Carlo Patrono, Cyclooxygenase inhibitors: From pharmacology to clinical read-outs. Biochimica et Biophysica Acta. ,vol. 1851, pp. 422- 432 ,(2015) , 10.1016/J.BBALIP.2014.09.016
Burkhard Hinz, Olga Cheremina, Kay Brune, Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man The FASEB Journal. ,vol. 22, pp. 383- 390 ,(2008) , 10.1096/FJ.07-8506COM
Irina Nikolova, Jasmina Tencheva, Julian Voinikov, Valentina Petkova, Niko Benbasat, Nikolai Danchev, Metamizole: A Review Profile of a Well-Known “Forgotten” Drug. Part I: Pharmaceutical and Nonclinical Profile Biotechnology & Biotechnological Equipment. ,vol. 26, pp. 3329- 3337 ,(2012) , 10.5504/BBEQ.2012.0089
Daniel L. Simmons, Regina M. Botting, Timothy Hla, Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition Pharmacological Reviews. ,vol. 56, pp. 387- 437 ,(2004) , 10.1124/PR.56.3.3