Hexose transport regulation in cultured hamster cells.

作者: C. William Christopher

DOI: 10.1002/JSS.400060403

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摘要: Hamster (nil) cells maintained overnight in culture medium containing cyclohemiximide and either glucose or fructose exhibit strikingly different rates of hexose transport metabolism (i.e. uptake). Pretreatment cultures with sulfhydryl reagents makes it possible to determine initial for a physiological sugar such as galactose which is catabolite hamster cells. Using model, uptake enhancements can now be shown due almost entirely increases the rate step. The regulation best accounted by model comprised 2 antagonizing mechanism. This involves turnover carriers well inhibitory units ("regulators"). experimental theoretical may also apply well-known observed oncogenically transformed

参考文章(15)
Rolf F. Kletzien, James F. Perdue, The Inhibition of Sugar Transport in Chick Embryo Fibroblasts by Cytochalasin B Journal of Biological Chemistry. ,vol. 248, pp. 711- 719 ,(1973) , 10.1016/S0021-9258(19)44431-1
C. William Christopher, Wendy W. Colby, Donna Ullrey, Herman M. Kalckar, Comparative studies of glucose-fed and glucose-starved hamster cell cultures: responses in galactose metabolism. Journal of Cellular Physiology. ,vol. 90, pp. 387- 405 ,(1977) , 10.1002/JCP.1040900303
H. M. Kalckar, D. Ullrey, S. Kijomoto, S. Hakomori, Carbohydrate Catabolism and the Enhancement of Uptake of Galactose in Hamster Cells Transformed by Polyoma Virus Proceedings of the National Academy of Sciences of the United States of America. ,vol. 70, pp. 839- 843 ,(1973) , 10.1073/PNAS.70.3.839
Donna Ullrey, Maureen Thornton Gammon, Herman M. Kalckar, Uptake patterns and transport enhancements in cultures of hamster cells deprived of carbohydrates Archives of Biochemistry and Biophysics. ,vol. 167, pp. 410- 416 ,(1975) , 10.1016/0003-9861(75)90481-6
Helmut Holzer, Catabolite inactivation in yeast Trends in Biochemical Sciences. ,vol. 1, pp. 178- 181 ,(1976) , 10.1016/S0968-0004(76)80018-7
James A. Bassham, Mina J. Bissell, Rodney C. White, Quantitative tracer studies of metabolic dynamics of animal cells growing in tissue culture Analytical Biochemistry. ,vol. 61, pp. 479- 491 ,(1974) , 10.1016/0003-2697(74)90415-1
R. Martineau, M. Kohlbacher, S. N. Shaw, H. Amos, Enhancement of hexose entry into chick fibroblasts by starvation: differential effect on galactose and glucose. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 69, pp. 3407- 3411 ,(1972) , 10.1073/PNAS.69.11.3407
R. Dulbecco, G. Freeman, Plaque production by the polyoma virus Virology. ,vol. 8, pp. 396- 397 ,(1959) , 10.1016/0042-6822(59)90043-1
H. M. Kalckar, D. Ullrey, Two Distinct Types of Enhancement of Galactose Uptake into Hamster Cells: Tumor-Virus Transformation and Hexose Starvation Proceedings of the National Academy of Sciences of the United States of America. ,vol. 70, pp. 2502- 2504 ,(1973) , 10.1073/PNAS.70.9.2502