p-Akt and its relationship with clinicopathological features and survival in oral squamous cell carcinoma: an immunohistochemical study.
作者： Hélder Antônio Rebelo Pontes , Flávia Sirotheau Corrêa Pontes , Adriana Souza de Jesus , Maiza Cristina Pereira Soares , Fábio Luiz Neves Gonçalves
DOI: 10.1111/JOP.12268
关键词:
摘要: Background The aim of this study was to evaluate, through immunohistochemical reaction in samples oral squamous cell carcinoma, the correlation between expression status protein kinase B (p-Akt) and patient survival as well histological grade some clinicopathological features. Methods Samples were collected from 46 patients with carcinoma. The p-Akt analysed, features including use tobacco, tumour stage, size infiltration metastatic lymph nodes. association immunostaining analysed 40 patients. associations examined for statistical significance using a chi-square test. Overall rates estimated by Kaplan–Meier method compared log rank test (P > 0.05). Results The results indicated statistically significant variables node metastasis (P = 0.006), (P = 0.044) rate (P = 0.0298). Conclusion From these results, present suggests that high found carcinoma may contribute growth, regional nodes shorter time.
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