E-cadherin expression and prognosis of oral cancer: a meta-analysis

摘要: This study aims to evaluate the association of E-cadherin expression with prognosis oral squamous cell carcinoma (OSCC). Literature retrieval, selection and assessment, data extraction, meta-analyses were performed according Revman 5.0 guidelines. In meta-analysis, we utilized either fixed effects or random model pool HR test heterogeneity. A total nine eligible studies included 973 OSCC patients analyzed. Of patients, 76.3 % had low cutoff value defined by authors. The pooled hazard ratio (HR) for overall survival (OS) was 0.65 (95 % CI 0.52 0.80, P < 0.001); in Asian population, reduced 0.84 0.75 0.95, P = 0.006), non-Asian 0.54 0.41 0.69, P < 0.001). Patients appear have a poorer OS compared those normal higher E-cadherin.