Polycomb group protein EZH2-mediated E-cadherin repression promotes metastasis of oral tongue squamous cell carcinoma.
作者： Cheng Wang , Xiqiang Liu , Zujian Chen , Hongzhang Huang , Yi Jin
DOI: 10.1002/MC.21848
关键词: Cadherin 、 Cell migration 、 Metastasis 、 Regulation of gene expression 、 Carcinoma 、 Biology 、 Gene knockdown 、 EZH2 、 Tumor suppressor gene 、 Cancer research
摘要: … Our results provide evidence suggesting a critical role of EZH2 in the acquisition of an aggressive and/or metastatic phenotype in OTSCC. Furthermore, EZH2-mediated cell migration is …
sci-hub.se 参考文章(26)
Anxun Wang, Xiqiang Liu, Shihu Sheng, Hui Ye, Tingsheng Peng, Fei Shi, David L Crowe, Xiaofeng Zhou, Dysregulation of heat shock protein 27 expression in oral tongue squamous cell carcinoma BMC Cancer. ,vol. 9, pp. 167- 167 ,(2009) , 10.1186/1471-2407-9-167
Q Cao, J Yu, S M Dhanasekaran, J H Kim, R-S Mani, S A Tomlins, R Mehra, B Laxman, X Cao, J Yu, C G Kleer, S Varambally, A M Chinnaiyan, Repression of E-cadherin by the polycomb group protein EZH2 in cancer Oncogene. ,vol. 27, pp. 7274- 7284 ,(2008) , 10.1038/ONC.2008.333
Anke Sparmann, Maarten van Lohuizen, Polycomb silencers control cell fate, development and cancer Nature Reviews Cancer. ,vol. 6, pp. 846- 856 ,(2006) , 10.1038/NRC1991
Lu Jiang, Xiqiang Liu, Antonia Kolokythas, Jinsheng Yu, Anxun Wang, Caroline E. Heidbreder, Fei Shi, Xiaofeng Zhou, Downregulation of the Rho GTPase signaling pathway is involved in the microRNA-138-mediated inhibition of cell migration and invasion in tongue squamous cell carcinoma. International Journal of Cancer. ,vol. 127, pp. 505- 512 ,(2010) , 10.1002/IJC.25320
Sooryanarayana Varambally, Saravana M. Dhanasekaran, Ming Zhou, Terrence R. Barrette, Chandan Kumar-Sinha, Martin G. Sanda, Debashis Ghosh, Kenneth J. Pienta, Richard G. A. B. Sewalt, Arie P. Otte, Mark A. Rubin, Arul M. Chinnaiyan, The polycomb group protein EZH2 is involved in progression of prostate cancer Nature. ,vol. 419, pp. 624- 629 ,(2002) , 10.1038/NATURE01075
Chiu M. Ho, Kam H. Lam, William I. Wei, Sai K. Lau, Lai K. Lam, Occult lymph node metastasis in small oral tongue cancers. Head and Neck-journal for The Sciences and Specialties of The Head and Neck. ,vol. 14, pp. 359- 363 ,(1992) , 10.1002/HED.2880140504
Wei Cao, Zhien Feng, Zhibin Cui, Chenping Zhang, Zhaoyao Sun, Li Mao, Wantao Chen, Up-regulation of enhancer of zeste homolog 2 is associated positively with cyclin D1 overexpression and poor clinical outcome in head and neck squamous cell carcinoma. Cancer. ,vol. 118, pp. 2858- 2871 ,(2012) , 10.1002/CNCR.26575
W BIRCHMEIER, J BEHRENS, Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. ,vol. 1198, pp. 11- 26 ,(1994) , 10.1016/0304-419X(94)90003-5
T Sudo, T Utsunomiya, K Mimori, H Nagahara, K Ogawa, H Inoue, S Wakiyama, H Fujita, K Shirouzu, M Mori, Clinicopathological significance of EZH2 mRNA expression in patients with hepatocellular carcinoma British Journal of Cancer. ,vol. 92, pp. 1754- 1758 ,(2005) , 10.1038/SJ.BJC.6602531
Anthony Po Wing Yuen, King Yin Lam, Alexander Chak Lam Chan, William Ignace Wei, Lai Kuen Lam, Wai Kuen Ho, Chiu Ming Ho, None, Clinicopathological analysis of elective neck dissection for N0 neck of early oral tongue carcinoma. American Journal of Surgery. ,vol. 177, pp. 90- 92 ,(1999) , 10.1016/S0002-9610(98)00294-3