Fibrosis in chronic hepatitis C acquired in infancy: is it only a matter of time?
作者： Maria Guido , Flavia Bortolotti , Gioacchino Leandro , Paloma Jara , Loreto Hierro
DOI: 10.1016/S0002-9270(02)06015-X
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摘要: Abstract Objective The natural history of chronic hepatitis C acquired in infancy is not well understood. progression fibrosis was analyzed untreated children with virus infection and no other hepatotoxic cofactors. Methods A total 112 pediatric patients (13 paired liver biopsies) were considered. Fibrosis assessed by METAVIR score (i.e., stage F1 to F4). ratio between the (METAVIR units) presumed duration represented “estimated” rate per year. In biopsies, “observed” defined as difference two biopsies divided time interval them. Results Both age at biopsy correlated (p Conclusions Chronic childhood a progressive, slow-moving, fibrotic disease. inferred on basis linear mathematical models should be critically evaluated clinical practice.
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