Hepatitis C virus.

摘要: Hepatitis C virus (HCV), a member of the genus Hepacivirus in Flaviviridae family, is single-stranded RNA that infects humans and other higher primates has selective tropism to liver. Although HCV particle itself difficult demonstrate, by inferring from virions Flaviviridae, putative composed nucleocapsid core protein viral RNA, surrounded phospholipid membrane which envelope proteins are embedded. The replication cycle can be divided into stages: binding entry cell; polyprotein translation processing; replication; packaging, assembly, release virion. current recommendations for disinfecting reusable endoscopic equipment mechanical washing with detergent soaking 2% glutaraldehyde were shown sufficient eliminate contamination HCV. transmitted vertically mother child. Successful eradication hepatitis antiviral treatment significantly reduces, but does not completely, risk chronic (CHC). Serologic assays detecting infection rapidly developed improved following initial discovery because urgent need screen blood donors prevent transmission. In general, indicated any adult patient CHC who viremic elevated aminotransferases or histologic evidence progressive liver disease, i.e., fibrosis extending beyond portal tracts.