Influence of interleukin-6 and G174C polymorphism in IL-6 gene on obesity and energy balance.
作者： K. Popko , E. Gorska , U. Demkow
DOI: 10.1186/2047-783X-15-S2-123
关键词:
摘要: Obesity is a multifactor disease with very complicated etiology. Genetic factors play an important role in the development of primary obesity. They may be responsible for up to 40% causes leading There are great number genes affecting food intake and energy expenditure. Serious consequences accompanying obesity, e.g., type 2 diabetes lipid abnormalities caused by increased level proinflammatory cytokines, such as IL-1, IL-6, TNF. It possible that polymorphisms located cytokine affect protein expression. known IL-6 plays metabolism The polymorphism found point 174 (G 174C) promoter region gene affects interleukin-6 expression and, consequently, lead obesity correlated conditions.
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