Inhibition of Borna disease virus multiplication by interferon: cell line differences in susceptibility.

摘要: It has previously been reported that de novo infection of primary rabbit brain cells with Borna disease virus (BDV) can be blocked interferon-α/β (IFN), whereas this cytokine no inhibitory effect on BDV in persistently infected rat lung [v. Rheinbaben et al., J. Gen. Virol. (1985) 66: 2 777–2 780]. remained unclear, however, whether these results indicated IFN exclusively targets early steps the replication cycle or they simply reflected cell line differences. We now show was effectively inhibited by both acutely and monkey Vero cells. By contrast, had clear protective either persistent infections C6 glioblastoma protected from cytopathic effects vesicular stomatitis virus, excluding possibility are devoid a functional system. In fibroblasts human oligodendroglial line, induced an efficient antiviral state against BDV. These indicate is highly susceptible to some lines, while others seem lack undefined components system which mediate protection