Experimental hematogenous infection of subcutaneously implanted foreign bodies.

摘要: Implanted foreign bodies are highly susceptible to pyogenic infection. Whereas infection up 3 months after surgery is probably due perioperative bacterial contamination, little known about the pathogenesis of late prosthetic infections. We employed an animal model determine whether subcutaneously implanted were experimental bacteremia. Tissue cages into guinea pigs, which infected at earliest 4 weeks later by intracardiac injection Staphylococcus aureus Wood 46. The 2×106 cfu did not result in any Inoculation 5×107 resulted a bacteremia 102–103 cfu/ml 5 min and led 11/26 selective tissue cage infections with no microbiological evidence elsewhere. Higher inocula caused systemic foci different organs. Rifampin (7.5 mg/kg b.i.d.) was administered for 48 h, starting times establish best timing efficacious short-term therapy. ...