Wearable Microsystem for Minimally Invasive, Pseudo-Continuous Blood Glucose Monitoring: The e-Mosquito

摘要: This paper presents a wearable microsystem for minimally invasive, autonomous, and pseudo-continuous blood glucose monitoring, addressing growing demand replacing tedious fingerpricking tests diabetic patients. Unlike prevalent solutions which estimate levels from interstitial fluids or tears, our design extracts whole sample small lanced skin wound using novel shape memory alloy (SMA)-based microactuator directly measures the level sample. In vitro characterization determined that SMA produced penetration force of 225 gf, depth 3.55 mm, consumed approximately 5.56 mW·h triggering. The microactuation mechanism was also evaluated by extracting samples wrist four human volunteers. A total 19 out 23 actuations successfully reached capillary vessels below wrists producing droplets on surface skin. integrated potentiostat-based sensing circuit e-Mosquito device showed good linear correlation ( R 2 = 0.9733) with measurements standard monitoring technology. These proof-of-concept studies demonstrate feasibility autonomous intermittent monitoring.