MRI of the corpus callosum in multiple sclerosis: association with disability.
作者： A. Ozturk , SA Smith , EM Gordon-Lipkin , DM Harrison , N. Shiee
关键词:
摘要: Inflammatory demyelination and axon damage in the corpus callosum are prominent features of multiple sclerosis (MS) may partially account for impaired performance on complex tasks. The objective this article was to characterize quantitative callosal MRI abnormalities their association with disability. In 69 participants MS 29 healthy volunteers, lesional extralesional indices were estimated via diffusion tensor tractography. expanded disability status scale (EDSS) functional composite (MSFC) scores recorded 53 MS. All tested diffusely abnormal EDSS score correlated only age (r = 0.51). Scores overall MSFC its paced serial auditory addition test (PASAT) 9-hole peg components fractional anisotropy 0.27, 0.35, 0.31, respectively) perpendicular diffusivity -0.29, -0.30, -0.31) but not volume or lesion volume; PASAT more weakly magnetization-transfer ratio 0.21). Anterior associated posterior slow test. conclusion, can be assessed cognitive upper-extremity dysfunction
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