The interactions of ethanol with the benzodiazepine-GABA receptor-ionophore complex
作者： M.K. Ticku , T.P. Burch , W.C. Davis
DOI: 10.1016/0091-3057(83)90140-5
关键词:
摘要: Abstract Ethanol, barbiturates and benzodiazepines have similar pharmacological effects. All of these drugs facilitate the inhibitory transmission mediated by GABA administration increases number low affinity receptor sites, while, during ethanol withdrawal, this site is decreased. This decreased withdrawal correlated with audiogenic seizure activity. These results indicate that in vivo interacts receptors, interaction may be responsible for some effects symptoms withdrawal. like pentobarbital, also enhances [3H]diazepam binding to Lubrol-solubilized membrane fraction vitro. effect was dose-related blocked picrotoxinin other antagonists. Enhancement various alcohols did not correlate lipid: water partition coefficients. Ethanol partially inhibited [3H]-α-dihydropicrotoxinin fraction. ethanol, modulate benzodiazepine component benzodiazepine-GABA receptor-ionophore complex via site. The possible interpretation results, relation GABAergic transmission, discussed.
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sci-hub.se 参考文章(42)
Martyn W. Hill, A. D. Bangham, General depressant drug dependency : a biophysical hypothesis. Advances in Experimental Medicine and Biology. ,vol. 59, pp. 1- 9 ,(1975) , 10.1007/978-1-4757-0632-1_1
Volicer L, Biagioni Tm, Effect of ethanol administration and withdrawal on GABA receptor binding in rat cerebral cortex. Subst. Alcohol Actions/Misuse; (United States). ,vol. 3, pp. 31- ,(1982)
F Leeb-Lundberg, A Snowman, RW Olsen, Perturbation of benzodiazepine receptor binding by pyrazolopyridines involves picrotoxinin/barbiturate receptor sites The Journal of Neuroscience. ,vol. 1, pp. 471- 477 ,(1981) , 10.1523/JNEUROSCI.01-05-00471.1981
M.K. Ticku, Benzodiazepine-GABA receptor-ionophore complex. Current concepts. Neuropharmacology. ,vol. 22, pp. 1459- 1470 ,(1983) , 10.1016/0028-3908(83)90114-4
William C Davis, Maharaj K Ticku, Solubilization of the Picrotoxinin Binding Receptor from Mammalian Brain Journal of Neurochemistry. ,vol. 36, pp. 1572- 1579 ,(1981) , 10.1111/J.1471-4159.1981.TB00600.X
L VOLICER, T BIAGIONI, Effect of ethanol administration and withdrawal on benzodiazepine receptor binding in the rat brain Neuropharmacology. ,vol. 21, pp. 283- 286 ,(1982) , 10.1016/0028-3908(82)90200-3
ROBERT N. MCBURNEY, JEFFERY L. BARKER, GABA-induced conductance fluctuations in cultured spinal neurones. Nature. ,vol. 274, pp. 596- 597 ,(1978) , 10.1038/274596A0
J. Cott, A. Carlsson, J. Engel, M. Lindqvist, Suppression of ethanol-induced locomotor stimulation by GABA-like drugs. Naunyn-schmiedebergs Archives of Pharmacology. ,vol. 295, pp. 203- 209 ,(1976) , 10.1007/BF00505087
Sture Liljequist, Ulf Berggren, Jörgen Engel, Effect of ethanol on central gabaergic mechanisms Drug and Alcohol Dependence. ,vol. 6, pp. 74- 75 ,(1980) , 10.1016/0376-8716(80)90403-2
Maharaj K. Ticku, Richard W. Olsen, Interaction of barbiturates with dihydropicrotoxinin binding sites related to the GABA receptor-ionophore system Life Sciences. ,vol. 22, pp. 1643- 1651 ,(1978) , 10.1016/0024-3205(78)90061-9