Oligomeric forms of the metastasis-related Mts1 (S100A4) protein stimulate neuronal differentiation in cultures of rat hippocampal neurons.
作者： Vera Novitskaya , Mariam Grigorian , Marina Kriajevska , Svetlana Tarabykina , Igor Bronstein
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摘要: Neuronal differentiation and axonal growth are controlled by a variety of factors including neurotrophic factors, extracellular matrix components, cell adhesion molecules. Here we describe novel very efficient neuritogenic factor, the metastasis-related Mts1 protein, belonging to S100 protein family. The oligomeric but not dimeric form strongly induces cultured hippocampal neurons. A mutant with single Y75F amino acid substitution, which stabilizes Mts1, is unable promote neurite extension. Disulfide bonds do play an essential role in activity. Mts1-stimulated outgrowth involves activation phospholipase C kinase C, depends on intracellular level Ca(2+), requires signal-regulated kinases (ERKs) 1 2.
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