Obesity and diabetes

摘要: Obesity, particularly truncal obesity, is closely correlated to the prevalence of diabetes and cardiovascular disease. Plasma leptin, tumour necrosis factor-alpha non-esterified fatty acid levels are all elevated in obesity play a role causing insulin resistance. Diabetic glycaemic control resistance improve with reductions but treatment difficult, sustained weight reduction rarely occurs dietary management alone. Hypocaloric diets should be combined education low-impact exercise, as well behavioural techniques used encourage long-term changes. Weight-reducing drugs have only part such total package. Newer anti-obesity orlistat sibutramine tolerated been shown diabetes. It probable that developed future will act at different sites pathways regulating body weight, they may combination.