Allopregnanolone induces LHRH and glutamate release through NMDA receptor modulation.

摘要: LHRH release from hypothalamus is influenced by the neurotransmitter glutamate that acts, among others, on NMDA receptors present in neurons. On other hand, neurosteroid allopregnanolone can modulate activity of specific and affect release. We examined role vitro mediobasal anterior preoptic area ovariectomized rats with estrogen progesterone replacement. Moreover, we evaluated whether might act through modulation receptors. Allopregnanolone induced an increase This effect was reversed when were blocked antagonist 2-amino-7-phosphonoheptanoic acid (AP-7) indicating this would interact Moreover augment K+ evoked [3H]-glutamate hypothalamus-anterior explants also AP-7. These results suggest important physiologic function regulation neuroendocrine female adult rats. Not only appears to be involved enhancing but which critical control