Negative regulatory receptors of the IL-1 family

摘要: The IL-1 family of ligands and receptors has a central role in both innate adaptive immune responses is tightly controlled by antagonists, decoy receptors, scavengers, dominant negative molecules, miRNAs other mechanisms, acting extracellularly or intracellularly. During evolution, the development multiple mechanisms regulation reveals need for tight control biological consequences order to balance local systemic inflammation limit immunopathology. Indeed, studies with gene targeted mice regulators genetic humans provide evidence their non-redundant controlling inflammation, tissue damage responses. In addition, have revealed not only disease, but also homeostatic conditions. this review, mediated are presented include IL-1R2 IL-IL-18BP as well atypical which TIR8/SIGIRR, IL-1RAcPb, TIGIRR-1 IL-1RAPL. Particular emphasis given IL-1R2, since its discovery basis formulation paradigm, now considered general strategy counter primary inflammatory activities cytokines chemokines. Emphasis TIR8, prototypical regulatory receptor having roles limiting