Transcriptional regulation of T cell metabolism.
作者： Kenneth P. Hough , Danielle A. Chisolm , Amy S. Weinmann
DOI: 10.1016/J.MOLIMM.2015.07.038
关键词:
摘要: T cells express specific metabolic programs to promote diverse cellular differentiation states. The activation of naive upregulates the expression genes encoding components glycolysis, glutaminolysis, and lipid biosynthesis pathways robust proliferation effector cell activity. In contrast, memory downregulate these predominantly rely on catabolic for long-term survival. Dynamic changes in part define which are utilized current data suggest that key transcription factors involved specialization decisions, including T-bet, Bcl-6, HIF1, IRF4 Myc, link selective programming metabolism with fate decisions. this review, we will highlight transcriptional regulatory events differentiation.
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