Molecular regulation of effector and memory T cell differentiation
作者： John T Chang , E John Wherry , Ananda W Goldrath
DOI: 10.1038/NI.3031
关键词:
摘要: Immunological memory is a cardinal feature of adaptive immunity and an important goal vaccination strategies. Here we highlight advances in the understanding diverse T lymphocyte subsets that provide acute long-term protection from infection. These include new insights into transcription factors, upstream 'pioneering' factors regulate their accessibility to key sites gene regulation, as well metabolic regulators contribute differentiation effector subsets; ontogeny defining characteristics tissue-resident lymphocytes; origins remarkable heterogeneity exhibited by activated cells. Collectively, these findings underscore progress delineating underlying pathways control diversification cell responses but also reveal gaps knowledge, challenges arise application this knowledge rationally elicit desired through immunotherapy.
nature.com
sci-hub.se 参考文章(144)
Angelique Bellemare-Pelletier, Taras Kreslavsky, Ananda Goldrath, Kutlu Elpek, Michael L Dustin, Paul Monach, Sean Bendall, Natalie A Bezman, Harald von Boehmer, Lewis L Lanier, Aviv Regev, Vladimir Jojic, Susan A Shinton, Miriam Merad, Garry P Nolan, Emmanuel L Gautier, Tracy Heng, Shannon Turley, Amy Wagers, Matthew H Spitzer, Gundula Min-Oo, Tal Shay, Anne Fletcher, Brian Brown, Tata Nageswara Rao, Michael Brenner, Deepali Malhotra, David A Blair, Jim Collins, David Laidlaw, Katelyn Sylvia, Jamie Knell, Nadia Cohen, Derrick J Rossi, Jennifer Miller, Nidhi Malhotra, Joseph C Sun, Charlie C Kim, Katherine Rothamel, Joonsoo Kang, Daniel Gray, Jeffrey Ericson, Koichi Kobayashi, Richard R Hardy, Diane Mathis, Daphne Koller, Christophe Benoist, Francis Kim, Richard Cruse, Roi Gazit, Patrick Brennan, Michael Mingueneau, Gwendalyn J Randolph, Adam J Best, Claudia Jakubzick, Adriana Ortiz-Lopez, The transcriptional landscape of αβ T cell differentiation PMC. ,(2013)
Valerie P. Zediak, Jonathan B. Johnnidis, E. John Wherry, Shelley L. Berger, Cutting Edge: Persistently Open Chromatin at Effector Gene Loci in Resting Memory CD8+ T Cells Independent of Transcriptional Status Journal of Immunology. ,vol. 186, pp. 2705- 2709 ,(2011) , 10.4049/JIMMUNOL.1003741
Candace M. Cham, Thomas F. Gajewski, Glucose Availability Regulates IFN-γ Production and p70S6 Kinase Activation in CD8+ Effector T Cells The Journal of Immunology. ,vol. 174, pp. 4670- 4677 ,(2005) , 10.4049/JIMMUNOL.174.8.4670
Julia Rolf, Marouan Zarrouk, David K. Finlay, Marc Foretz, Benoit Viollet, Doreen A. Cantrell, AMPKα1: A glucose sensor that controls CD8 T-cell memory European Journal of Immunology. ,vol. 43, pp. 889- 896 ,(2013) , 10.1002/EJI.201243008
Shuyu Yao, Bruno Fernando Buzo, Duy Pham, Li Jiang, Elizabeth J. Taparowsky, Mark H. Kaplan, Jie Sun, Interferon Regulatory Factor 4 Sustains CD8+ T Cell Expansion and Effector Differentiation Immunity. ,vol. 39, pp. 833- 845 ,(2013) , 10.1016/J.IMMUNI.2013.10.007
Travis A. Doering, Alison Crawford, Jill M. Angelosanto, Michael A. Paley, Carly G. Ziegler, E. John Wherry, Network analysis reveals centrally connected genes and pathways involved in CD8+ T cell exhaustion versus memory. Immunity. ,vol. 37, pp. 1130- 1144 ,(2012) , 10.1016/J.IMMUNI.2012.08.021
Janelle A. Olson, Cameron McDonald-Hyman, Stephen C. Jameson, Sara E. Hamilton, Effector-like CD8+ T cells in the memory population mediate potent protective immunity Immunity. ,vol. 38, pp. 1250- 1260 ,(2013) , 10.1016/J.IMMUNI.2013.05.009
Michael Mingueneau, Taras Kreslavsky, Daniel Gray, Tracy Heng, Richard Cruse, Jeffrey Ericson, Sean Bendall, Matthew H Spitzer, Garry P Nolan, Koichi Kobayashi, Harald Von Boehmer, Diane Mathis, Christophe Benoist, Adam J Best, Jamie Knell, Ananda Goldrath, Vladimir Jojic, Daphne Koller, Tal Shay, Aviv Regev, Nadia Cohen, Patrick Brennan, Michael Brenner, Francis Kim, Tata Nageswara Rao, Amy Wagers, Katherine Rothamel, Adriana Ortiz-Lopez, Natalie A Bezman, Joseph C Sun, Gundula Min-Oo, Charlie C Kim, Lewis L Lanier, Jennifer Miller, Brian Brown, Miriam Merad, Emmanuel L Gautier, Claudia Jakubzick, Gwendalyn J Randolph, Paul Monach, David A Blair, Michael L Dustin, Susan A Shinton, Richard R Hardy, David Laidlaw, Jim Collins, Roi Gazit, Derrick J Rossi, Nidhi Malhotra, Katelyn Sylvia, Joonsoo Kang, Anne Fletcher, Kutlu Elpek, Angelique Bellemare-Pelletier, Deepali Malhotra, Shannon Turley, Immunological Genome Consortium, The transcriptional landscape of αβ T cell differentiation Nature Immunology. ,vol. 14, pp. 619- 632 ,(2013) , 10.1038/NI.2590
Roxane Tussiwand, Wan-Ling Lee, Theresa L. Murphy, Mona Mashayekhi, Wumesh KC, Jörn C. Albring, Ansuman T. Satpathy, Jeffrey A. Rotondo, Brian T. Edelson, Nicole M. Kretzer, Xiaodi Wu, Leslie A. Weiss, Elke Glasmacher, Peng Li, Wei Liao, Michael Behnke, Samuel S. K. Lam, Cora T. Aurthur, Warren J. Leonard, Harinder Singh, Christina L. Stallings, L. David Sibley, Robert D. Schreiber, Kenneth M. Murphy, Compensatory dendritic cell development mediated by BATF–IRF interactions Nature. ,vol. 490, pp. 502- 507 ,(2012) , 10.1038/NATURE11531
Ruoning Wang, Douglas R Green, Metabolic checkpoints in activated T cells Nature Immunology. ,vol. 13, pp. 907- 915 ,(2012) , 10.1038/NI.2386