Network analysis reveals centrally connected genes and pathways involved in CD8+ T cell exhaustion versus memory.
作者： Travis A. Doering , Alison Crawford , Jill M. Angelosanto , Michael A. Paley , Carly G. Ziegler
DOI: 10.1016/J.IMMUNI.2012.08.021
关键词: Transcription (biology) 、 Signal transduction 、 Transcription factor 、 Biology 、 Regulation of gene expression 、 Genetics 、 Gene expression 、 Gene regulatory network 、 Gene expression profiling 、 Cell biology 、 Gene
摘要: … We used transcriptional network analysis to begin to define which genes and biological pathways were central to CD8 T cell exhaustion. This approach revealed several key insights …
core.ac.uk
els-cdn.com参考文章(53)
Andy M Yip, Steve Horvath, Gene network interconnectedness and the generalized topological overlap measure. BMC Bioinformatics. ,vol. 8, pp. 22- 22 ,(2007) , 10.1186/1471-2105-8-22
Michael J. Fuller, Allan J. Zajac, Ablation of CD8 and CD4 T Cell Responses by High Viral Loads Journal of Immunology. ,vol. 170, pp. 477- 486 ,(2003) , 10.4049/JIMMUNOL.170.1.477
Marc RJ Carlson, Bin Zhang, Zixing Fang, Paul S Mischel, Steve Horvath, Stanley F Nelson, Gene connectivity, function, and sequence conservation: predictions from modular yeast co-expression networks. BMC Genomics. ,vol. 7, pp. 40- 40 ,(2006) , 10.1186/1471-2164-7-40
Peter Langfelder, Steve Horvath, Eigengene networks for studying the relationships between co-expression modules BMC Systems Biology. ,vol. 1, pp. 54- 54 ,(2007) , 10.1186/1752-0509-1-54
Peter Langfelder, Steve Horvath, WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics. ,vol. 9, pp. 559- 559 ,(2008) , 10.1186/1471-2105-9-559
Patrick O. Brown, David Botstein, Exploring the new world of the genome with DNA microarrays Nature Genetics. ,vol. 21, pp. 33- 37 ,(1999) , 10.1038/4462
Peter Langfelder, Rui Luo, Michael C. Oldham, Steve Horvath, Is My Network Module Preserved and Reproducible? PLoS Computational Biology. ,vol. 7, pp. e1001057- ,(2011) , 10.1371/JOURNAL.PCBI.1001057
Michael Reich, Ted Liefeld, Joshua Gould, Jim Lerner, Pablo Tamayo, Jill P Mesirov, GenePattern 2.0. Nature Genetics. ,vol. 38, pp. 500- 501 ,(2006) , 10.1038/NG0506-500
Lukas Baitsch, Petra Baumgaertner, Estelle Devêvre, Sunil K. Raghav, Amandine Legat, Leticia Barba, Sébastien Wieckowski, Hanifa Bouzourene, Bart Deplancke, Pedro Romero, Nathalie Rufer, Daniel E. Speiser, Exhaustion of tumor-specific CD8(+) T cells in metastases from melanoma patients Journal of Clinical Investigation. ,vol. 121, pp. 2350- 2360 ,(2011) , 10.1172/JCI46102
Lucinda K. Southworth, Art B. Owen, Stuart K. Kim, Aging Mice Show a Decreasing Correlation of Gene Expression within Genetic Modules PLoS Genetics. ,vol. 5, pp. e1000776- ,(2009) , 10.1371/JOURNAL.PGEN.1000776