Ablation of CD8 and CD4 T Cell Responses by High Viral Loads

摘要: To evaluate the impact of sustained viral loads on anti-viral T cell responses we compared that cleared acute lymphocytic choriomeningitis virus infection with those were elicited but could not resolve chronic infection. During infection, as replicating was cleared, CD8 down-regulated, and a pool resting memory cells developed. In chronically infected hosts, failure to control associated pronounced prolonged activation virus-specific cells. Nevertheless, there progressive diminution their effector activities capacity produce first IL-2, then TNF-alpha, finally IFN-gamma lost. Chronic also differential contraction certain responses, resulting in altered immunodominance. However, this immunodominance due selective expansion expressing particular TCR Vbeta segments during High only ablation impaired production IL-2 by CD4 Taken together, our data show exposure high results functional inactivation which may further promote persistence.