Comparison of fundamental and wideband harmonic contrast imaging of liver tumors

作者: F. Forsberg , J.B. Liu , H.J. Chiou , N.M. Rawool , L. Parker

DOI: 10.1016/S0041-624X(99)00149-3

关键词:

摘要: Wideband harmonic imaging (with phase inversion for improved tissue suppression) was compared to fundamental in vivo Four woodchucks with naturally occurring liver tumors were injected Imagent® (Alliance Pharmaceutical Corp., San Diego, CA) Randomized combinations of dose (0.05, 0.2 and 0.4 ml/kg) acoustic output power (AO; 5, 25 63% or MI ≤ 0.9) imaged gray scale using a Sonoline Elegra scanner (Siemens Medical Systems, Issaquah, WA). Tumor vascularity, conspicuity contrast enhancement rated by three independent observers. Imagent produced marked tumor depiction neovascularity at all dosages AO settings both modes. vascularity correlated mode, (P<0.002). Fundamental more (P<0.05), but best appreciated mode (P<0.05). Under the conditions studied here, approach wideband ml/kg an 25%.

参考文章(11)
Barry B. Goldberg, Ultrasound Contrast Agents ,(1996)
Beth A. Schrope, Vernon L. Newhouse, Second harmonic ultrasonic blood perfusion measurement Ultrasound in Medicine & Biology. ,vol. 19, pp. 567- 579 ,(1993) , 10.1016/0301-5629(93)90080-8
D.H. Simpson, Chien Ting Chin, P.N. Burns, Pulse inversion Doppler: a new method for detecting nonlinear echoes from microbubble contrast agents IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control. ,vol. 46, pp. 372- 382 ,(1999) , 10.1109/58.753026
Laurence Needleman, Flemming Forsberg, Contrast Agents in Ultrasound Ultrasound Quarterly. ,vol. 13, pp. 121- 138 ,(1995) , 10.1097/00013644-199509000-00001
B. Schrope, V.L. Newhouse, V. Uhlendorf, Simulated capillary blood flow measurement using a nonlinear ultrasonic contrast agent. Ultrasonic Imaging. ,vol. 14, pp. 134- 158 ,(1992) , 10.1177/016173469201400204
N. de Jong, R. Cornet, C.T. Lancée, Higher harmonics of vibrating gas-filled microspheres. Part two: measurements Ultrasonics. ,vol. 32, pp. 455- 459 ,(1994) , 10.1016/0041-624X(94)90065-5
Christopher S. Chapman, Ultrasound imaging system employing phase inversion subtraction to enhance the image The Journal of the Acoustical Society of America. ,vol. 103, pp. 1251- ,(1998) , 10.1121/1.423228
N. de Jong, R. Cornet, C.T. Lancée, Higher harmonics of vibrating gas-filled microspheres. Part one: simulations Ultrasonics. ,vol. 32, pp. 447- 453 ,(1994) , 10.1016/0041-624X(94)90064-7
G. Tyler, R. L. Snyder, J. Summers, Chronic hepatitis and hepatocellular carcinoma associated with woodchuck hepatitis virus. American Journal of Pathology. ,vol. 107, pp. 422- 425 ,(1982)
F Forsberg, J B Liu, D A Merton, N M Rawool, B B Goldberg, Parenchymal enhancement and tumor visualization using a new sonographic contrast agent Journal of Ultrasound in Medicine. ,vol. 14, pp. 949- 957 ,(1995) , 10.7863/JUM.1995.14.12.949