Review: Cancer‐Induced Autoimmunity in the Rheumatic Diseases

摘要: Tantalizing connections between autoimmune rheumatic diseases and cancer have become increasingly evident over the past several decades. These are complex, with different relationships in frequency, timing types of cancers observed or disease subgroups. Several recent advances from disparate fields begun to illuminate dynamic bidirectional interactions occurring at cancer-immune system interface which may be relevant understanding origins autoimmunity (1). include existence potent anti-cancer immune responses limit tumor growth, as well multiple inflammatory pathways that can contribute growth robustness. The striking ability checkpoint inhibitors reveal powerful patients highlight natural exist, regulate emergence (2). Recent data systemic sclerosis (SSc, scleroderma) suggests that, some cases, initiated by autoantigen mutation patient’s (3, 4). Interestingly, there exist same form scleroderma an identical response who do not a detectable cancer, raising possibility these patients, mechanism is except anti-tumor has successfully eliminated cancer. Similar associations also apparent other phenotypes, particularly dermatomyositis (DM). therefore provide exceptional opportunity study interactions, interrogate mechanisms diseases, humans.