The autoimmune myopathies

摘要: The autoimmune myopathies (also known as myositis) comprise an important group of disorders in which skeletal muscle is one the primary targets response. immune responses these target a limited set ubiquitously expressed autoantigens, and there striking association specific autoantibodies with distinct clinical phenotypes. Several features diseases, including cancer, induction disease response to statins, preferential expression myositis-specific autoantigens regenerating but not resting cells, have provided insights into initiating propagating mechanisms. Emerging data suggest model initiation propagation may be separated time and, potentially, space. In this model, increased cells focuses injury on healing injury, establishing self-sustaining loop immune-mediated repair. Such loops amenable novel therapeutic interventions.