Aggressive and fatal statin-induced dermatomyositis: a case report

作者: Raíssa Massaia Londero Chemello , Ana Maria Benvegnú , Lia Natália Diehl Dallazem , Diego Chemello

DOI: 10.1093/OMCR/OMX063

关键词:

摘要: Statins are widely used and currently the state-of-the-art treatment for primary secondary prevention of cardiovascular disease. Although statins generally well tolerated present an excellent safety profile, adverse effects from muscle toxicity may occur in some patients. Statin-induced dermatomyositis (DM) is a rare event associated with its use very few fatal cases have been reported. We case 69-year-old man early onset DM precipitated by small dose simvastatin. Despite immediate cessation agent systemic corticosteroids, took aggressive course. Such progression extremely unusual statin-induced DM. statins, we highlight importance identifying potential side this class medications. also emphasize correct diagnosis close follow-up patients statin effects.

参考文章(12)
Livia Casciola-Rosen, Antony Rosen, The autoimmune myopathies The Autoimmune Diseases (Fifth Edition). pp. 547- 554 ,(2014) , 10.1016/B978-0-12-384929-8.00039-3
Janneke Van De Vlekkert, Mario Maas, Jessica E. Hoogendijk, Marianne De Visser, Ivo N. Van Schaik, Combining MRI and muscle biopsy improves diagnostic accuracy in subacute-onset idiopathic inflammatory myopathy. Muscle & Nerve. ,vol. 51, pp. 253- 258 ,(2015) , 10.1002/MUS.24307
Olavo M. Vasconcelos, William W. Campbell, Dermatomyositis-like syndrome and HMG-CoA reductase inhibitor (statin) intake† Muscle & Nerve. ,vol. 30, pp. 803- 807 ,(2004) , 10.1002/MUS.20127
I. R. Zaraa, I. Labbene, D. Mrabet, H. Zribi, I. Chelly, M. Zitouna, M. Mokni, S. Sellami, A. B. Osman, Simvastatin-induced dermatomyositis in a 50-year-old man Case Reports. ,vol. 2011, ,(2011) , 10.1136/BCR.02.2011.3832
Sivakumar Sathasivam, Statin induced myotoxicity European Journal of Internal Medicine. ,vol. 23, pp. 317- 324 ,(2012) , 10.1016/J.EJIM.2012.01.004
Abhijit Ghatak, Osman Faheem, Paul D. Thompson, The genetics of statin-induced myopathy. Atherosclerosis. ,vol. 210, pp. 337- 343 ,(2010) , 10.1016/J.ATHEROSCLEROSIS.2009.11.033
Writing Committee Members:, Richard C Pasternak, Sidney C Smith Jr, C Noel Bairey-Merz, Scott M Grundy, James I Cleeman, Claude Lenfant, None, ACC/AHA/NHLBI Clinical Advisory on the Use and Safety of Statins Circulation. ,vol. 106, pp. 1024- 1028 ,(2002) , 10.1161/01.CIR.0000032466.44170.44
Judy A. Staffa, Jennie Chang, Lanh Green, Cerivastatin and reports of fatal rhabdomyolysis. The New England Journal of Medicine. ,vol. 346, pp. 539- 540 ,(2002) , 10.1056/NEJM200202143460721
Andrew L. Mammen, Statin-Associated Autoimmune Myopathy. The New England Journal of Medicine. ,vol. 374, pp. 664- 669 ,(2016) , 10.1056/NEJMRA1515161