The CXC Chemokine Murine Monokine Induced by IFN-γ (CXC Chemokine Ligand 9) Is Made by APCs, Targets Lymphocytes Including Activated B Cells, and Supports Antibody Responses to a Bacterial Pathogen In Vivo

摘要: Monokine induced by IFN-γ (Mig; CXC chemokine ligand 9) is an IFN-γ-inducible that signals through the receptor CXCR3 and known to function as a chemotactic factor for human T cells, particularly following cell activation. The mig gene can be in multiple types organs, Mig has been shown contribute infiltration into immune/inflammatory reactions peripheral tissues mice. We have investigated expression activities of mouse cells role models host defense Murine (Mu)Mig functioned resting memory activated both CD4 + CD8 , responsiveness MuMig correlated with surface MuCXCR3. Using −/− mice, we found was not necessary survival after infections number intracellular pathogens. Surprisingly, however, mice showed reductions 50–75% Abs produced against bacterium Francisella tularensis live vaccine strain. Furthermore, calcium chemotaxis B activation In addition, mumig APCs, including CD8α − dendritic cells. Together, our data suggest may important only recruit inflammatory sites, but also some cases maximize interactions among within lymphoid organs provide optimal humoral responses