T Cell Infiltration into Class II MHC-Disparate Allografts and Acute Rejection Is Dependent on the IFN-γ-Induced Chemokine Mig

摘要: Direct evidence that cytokines with chemoattractant properties for leukocytes, chemokines, recruit alloantigen-primed T cells into transplanted allografts has been lacking. We present neutralization of a single chemokine inhibits cell infiltration class II MHC-disparate murine and acute rejection. The chemokines IFN-γ-inducible protein-10 monokine induced by IFN-γ (Mig) are expressed in allogeneic skin grafts during the late stages Survival B6.H-2 bm12 is prolonged from day 14 to 55 posttransplant when C57BL/6 recipients given short course treatment an antiserum Mig. This also macrophage allografts. not rejected −/− recipients. Injection Mig directly on IFN-γ-deficient restores Therefore, inability reject due lack intraallograft production recruitment graft. These results indicate first time potential utility strategies preventing abrogating