Expression of chemokine genes during rejection and long-term acceptance of cardiac allografts.

摘要: Chemokines are cytokines with chemoattractant properties for leukocytes. They may play a critical role in directing leukocytes to graft sites and amplifying intragraft inflammation during rejection. Previous studies have tested the expression of chemokine genes rejection allogeneic skin grafts mice. In current study, we used heterotopic heart transplant model mice test these nonrejecting cardiac isografts, rejecting allografts, allografts that were accepted due immunosuppression gallium nitrate. With exception low levels interleukin-1beta JE, proinflammatory cytokine was not observed either isografts or native heart. Two distinct patterns mRNA allografts. Intra-allograft interleukin-1beta, interferon-gamma-inducible protein, KC prominent by day 3 after transplantation. The macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, regulated upon activation, normal T cell expressed secreted (RANTES) at undetectable transplantation but high 8 Sixty days transplantation, intra-allograft chemokines hearts from nitrate-treated recipients indicated MIP-1alpha, RANTES.