Resistance to graft-versus-host disease following small bowel transplantation.

摘要: Transplantation of a Lewis rat small bowel allograft (SBTx) into x Brown Norway F1 (LBNF1) hybrid recipients provokes lethal graft-versus-host disease. GVHD in rats inoculated with large number parental lymphocytes may be abrogated by prior treatment hybrids sublethal dose (SLD) the same lymphocytes. Therefore, we sought to determine whether this type immunomodulation would prevent after SBTx. We examined pretreatment LBNF1 SLD lymphocytes, or revascularized segment bowel, might ameliorate following transplantation entire bowel. Nonpretreated died Lew SBTx; 95% pretreated and 84% first transplanted survived induced SBTx 10 days later. Of BN none were protected from concluded that either an provides profound protection effects strain specificity.