Estrogen modulation: Tiered testing for human hazard evaluation

摘要: Recent concerns about the potential of certain chemicals to modulate estrogen-regulated processes have led questions as how should be tested for such effects. Therefore, AIHC has developed a comprehensive, resource-efficient, and flexible tiered strategy estrogen modulation (EM) testing. Levels evaluation include Tier 0, in which exposure, along with alerts based on structure-activity, persistence, bioaccumulation, other data, are assessed prioritize preliminary In I, short term vitro, ex vivo, and/or vivo assays used obtain indication EM potential. Among these, an response assay is considered most reliable at this time. However, none these tests intended risk assessment, but rather aid choosing further testing guiding extent that II aimed assessment involves whole animal contain EM-sensitive end points (e.g., two-generation reproduction study). III consists hypothesis-driven research reserved situations where targeted can reduce levels uncertainty. This approach provides framework strategic effective application test methods address specific information needs case by basis.