Pyrazole, triazole and tetrazole orexin receptor antagonists

作者: Scott D. Kuduk , Douglas Beshore , Yunfu Luo , Na Meng , Nigel Liverton

DOI:

关键词:

摘要: The present invention is directed to pyrazole, triazole and tetrazole compounds which are antagonists of orexin receptors. Such the general structural formula I: also uses described herein in potential treatment or prevention neurological psychiatric disorders diseases receptors involved. pharmaceutical compositions comprising these compounds. such

参考文章(53)
Anthony J. Roecker, Christopher D. Cox, Paul J. Coleman, Orexin Receptor Antagonists: New Therapeutic Agents for the Treatment of Insomnia. Journal of Medicinal Chemistry. ,vol. 59, pp. 504- 530 ,(2016) , 10.1021/ACS.JMEDCHEM.5B00832
Scott D. Kuduk, Jason W. Skudlarek, Piperidinyl alkyne orexin receptor antagonists ,(2012)
Mark E. Fraley, John D. Schreier, Christopher D. Cox, Disubstituted Azepan Orexin Receptor Antagonists ,(2009)
Anthony J. Roecker, Swati P. Mercer, Paul J. Coleman, Tertiary amide orexin receptor antagonists ,(2010)
John D. Schreier, Christopher D. Cox, Broc Flores, Paul J. Coleman, 2,5-disubstituted morpholine orexin receptor antagonists ,(2009)
Giovanni Palombi, Marco Farina, Jean-Philippe Rocher, Stefania Gagliardi, Emmanuel Le Poul, Novel Heterocyclic Compounds as Positive Allosteric Modulators of Metabotropic Glutamate Receptors ,(2006)
Christopher D. Cox, David B. Whitman, Michael J. Breslin, 2-substituted proline bis-amide orexin receptor antagonists ,(2007)
Anthony J. Roecker, Christopher D. Cox, Jeffrey M. Bergman, Paul J. Coleman, Substituted diazepan orexin receptor antagonists ,(2007)
Scott D. Kuduk, Christina Di Marco, 2,5-disubstituted thiomorpholine orexin receptor antagonists ,(2012)
John D. Schreier, Christopher D. Cox, Paul J. Coleman, 2,4-disubstituted pyrrolidine orexin receptor antagonists ,(2009)