Spinal cord ependymomas and myxopapillary ependymomas in the first 2 decades of life: a clinicopathological and immunohistochemical characterization of 19 cases

摘要: Object Primary spinal cord ependymomas (EPNs) are rare in children, comprising classical WHO Grade II and III tumors I myxopapillary (MEPNs). Despite their benign histology, recurrences neural-axis dissemination have been reported up to 33% MEPNs the pediatric population. Treatment options beyond resection limited, little is known about tumorigenesis. The purpose of this study was explore tumor biology outcomes a consecutive series patients treated at single institution. Methods authors performed retrospective clinicopathological review 19 tertiary referral children's hospital for ependymoma. population included 8 with pathological diagnosis MEPN 11 EPN (10 cases were 1 case III). upregulation following genes HOXB13, NEFL, PDGFRα, EGFR, EPHB3, AQP1, JAGGED studied by im...