Perineural Invasion Affects Biochemical Recurrence-Free Survival in Patients with Prostate Cancer Treated with Definitive External Beam Radiotherapy

摘要: OBJECTIVES To assess the prognostic effect of perineural invasion (PNI) for patients undergoing external beam radiotherapy prostate cancer. METHODS We evaluated 657 consecutive who had undergone clinically localized The clinical/treatment parameters used analysis included PNI, clinical stage, biopsy Gleason score, pretreatment prostate-specific antigen, radiation dose, and androgen deprivation. primary endpoint was biochemical recurrence defined by Radiation Therapy Oncology Group-American Society Therapeutic Radiology Phoenix consensus; secondary cancer death. RESULTS Of 586 men with a minimum 24 months follow-up, 112 (19.1%) PNI present in specimen. When were stratified into risk groups using National Comprehensive Cancer Network criteria, more prevalent within higher (6.8% low-risk versus 18.3% intermediate-risk 30.1% high-risk groups; P <0.001). presence associated lower recurrence-free (P = 0.003) cancer-specific 0.040) survival rates Kaplan-Meier analysis. Cox regression showed that statistically significant factor on both univariate (hazard ratio [HR] 1.71, 95% confidence interval [CI] 1.19 to 2.46, 0.004) multivariate (HR 1.57, CI 1.06 2.32, 0.025) analyses. Regression after stratification group adjustment treatment covariates demonstrated association between 4.14, 1.55 11.02, 0.005) intermediate/high-risk 1.53, 1.02 2.29, 0.040). CONCLUSIONS results our study have shown is an independent increased radiotherapy.