Perineural invasion and Gleason 7-10 tumors predict increased failure in prostate cancer patients with pretreatment PSA <10 ng/ml treated with conformal external beam radiation therapy
作者： Penny R Anderson , Alexandra L Hanlon , Arthur Patchefsky , Tahseen Al-Saleem , Gerald E Hanks
DOI: 10.1016/S0360-3016(98)00167-9
关键词:
摘要: Abstract Purpose: It has been well established that prostate cancer patients with pretreatment PSA Methods and Materials: Between 3/87 11/94, 266 T1-T3NXM0 values Results: Univariate analysis according to treatment factors for bNED control demonstrates a statistically significant improvement in 5-year Gleason score 2–6 vs. 7–10, without evidence of perineural invasion (PNI) those PNI, palpation stage T1/T2AB T2C/T3. Multivariate (p = 0.0496), PNI 0.0008) 0.0153) are independent predictors control. Based on these factors, stratified into more favorable prognosis group (Gleason 2–6, no T1/T2AB, n 172) less 7–10 or T2C/T3, 94). A comparison the two groups reveals is significantly lower (74% 91% at 5 years, p 0.0024). Conclusions: (1) This report identifies presence as T2C/T3 predict worse outcome
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