作者: Hunder Gg , Carson Cw , Johnson Cm , Beall Ld , Newman W
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摘要: OBJECTIVE To investigate the state of endothelial cell activation in vasculitis, scleroderma, and systemic lupus erythematosus (SLE). METHODS We used a sandwich ELISA to quantitate soluble form leukocyte adhesion molecule-1 (sELAM) serum. RESULTS sELAM was detected serum from healthy individuals (mean 0.92 ng/ml). Levels were significantly higher patients with giant arteritis 2.04 ng/ml), polyarteritis nodosa 2.08 scleroderma 2.27 SLE 3.93 Elevated values present both active inactive disease. levels > 3 ng/ml identified most recent onset or CONCLUSION Our findings may reflect low degree persons that is increased inflammatory diseases involving blood vessels. ongoing processes these diseases.