Sorting same-size red blood cells in deep deterministic lateral displacement devices

摘要: We study deformability-based sorting of same-size RBCs via DLD using an in-house integral equation solver. Our goal is to quantitatively characterize the physical mechanisms that enable cell separation. To this end, we systematically investigate effects interior fluid viscosity and membrane elasticity a on its behavior. In particular, consider deep devices in which can show rich dynamics such as taking particular angular orientation depending mechanical property. have found out cells moving with sufficiently high positive inclination angle respect flow direction displace laterally while those smaller angles travel streamlines. Thereby, possible. The underlying mechanism here migration due cell's shear gradient. higher is, farther laterally. also assess efficiency technique for dense suspensions. It turns most suspensions does not lateral no matter what their deformability is. As result, separating device becomes harder.