Probing long-range interactions by extracting free energies from genome-wide chromosome conformation capture data

摘要: Background A variety of DNA binding proteins are involved in regulating and shaping the packing chromatin. They aid formation loops that function to isolate different structural domains. A recent experimental technique, Hi-C, provides a method for determining frequency such looping between all distant parts genome. Given locations many chromatin associated have also been measured, it has possible make estimates their influence on long-range interactions as measured by Hi-C. However, challenge this analysis is predominance non-specific contacts mask out specific interest.