Clinical and epidemiological features of paracoccidioidomycosis due to Paracoccidioides lutzii.

摘要: Background The fungus Paracoccidioides lutzii was recently included as a new causative species of paracoccidioidomycosis (PCM) and most cases have been reported from Brazil. According to available epidemiological information, P. is concentrated in the Middle-West region Brazil, mainly state Mato Grosso. However, clinical laboratorial data on patients infected with remain extremely limited. Methodology/Main findings This work describes manifestations 34 suffering PCM caused by lutzii, treated along 5 years (2011–2017) at reference service center for systemic mycoses Grosso, Adult rural workers (men), aged between 28 67 predominated. All had chronic form disease, oral mucosa (n = 19; 55.9%), lymph nodes 23; 67.7%), skin 16; 47.1%) lung 28; 82.4%) were affected sites. Alcohol intake 55.9%) smoking 29; 85.3%) frequent habits among patients. No patient suffered any other life-threatening such tuberculosis, cancer or inflammatory infectious parasitic diseases. The positivity culture examination (97.1%) higher than that found direct mycological (88.2%). Particularly, one presented fungemia diagnosis, which lead his death. time elapsed initial symptoms initiation treatment 19.7 (31.5) months, diagnosed 7 months after symptoms’ onset. Conclusions/Significance Compared classical clinical-epidemiological profile brasiliensis, results this descriptive study did not show significant differences could be attributed lutzii. Future studies may confirm refute existence two fungal species.