Association of SOCS1 (- 820) (rs33977706) gene polymorphism with chronic periodontitis: A case-control study in Brazilians.

摘要: It is evident that the accumulation of periodontal pathogens over teeth surface triggers periodontitis; however, its aggravation and severity depend on other elements such as environmental factors, systemic health host genetic and/or epigenetic background. To address this issue, we investigated association two polymorphisms placed promoter region SOCS1 gene with chronic disease. regulates Jak/Kinase signaling pathway changes in mRNA expression have been related to different types cancer inflammation, including periodontitis. The frequency alleles genotypes (position − 820 (rs33977706) position − 1478 (rs33989964)) were analyzed by performing RFLP TaqMan system a total 257 non-smoking subjects. We found low A allele A/A genotype SOCS1− 820 polymorphism periodontitis group, especially when severe samples separately (OR = 0.3933; p = 0.0084 (IC95% 0.2112 < μ < 0.7324)), suggesting plays protective effect against did not find between SOCS1-1478 In addition, analysis SOCS1− 820/− 1478 haplotype revealed A− 820/CA− 1478 decreases ChrP (p = 0.0089). conclusion, our study associated