Behavioral Fever Drives Epigenetic Modulation of the Immune Response in Fish.

摘要: Ectotherms choose the best thermal conditions to mount a successful immune response, phenomenon known as behavioral fever. The cumulative evidence suggests that fever impacts positively upon lymphocyte proliferation, inflammatory cytokine expression and other functions. In this study, we have explored how choice during infection underpinning molecular processes temperature increase is coupled response. Our results show in widespread, plastic imprint on gene regulation proliferation. We further possible contribution of histone modification identified global associations between changes suggest epigenetic remodeling result Together, these highlight critical importance mobile ectotherms, particularly response an infection, demonstrate key role orchestrate thermocoupling