The human growth hormone gene family: structure and evolution of the chromosomal locus

摘要: Abstract The structure of the human growth hormone gene cluster has been determined over a 78 kilobase region DNA by study two overlapping cosmids. There are genes interspersed with three chorionic somatomammotropin genes, all in same transcriptional orientation. One lies an active chromatin conformation pituitary and at least one placenta. The groups highly homologous throughout their 5' flanking coding sequences, but diverge 3' regions which raises paradox how so similar structural sequences can be differentially regulated. Analysis identification different classes duplication units five suggests that evolved quite recently mechanism involved unequal exchange between middle repetitive elements Alu family.