A novel genomic alteration of LSAMP associates with aggressive prostate cancer in African American men
作者： Gyorgy Petrovics , Hua Li , Tanja Stümpel , Shyh-Han Tan , Denise Young
DOI: 10.1016/J.EBIOM.2015.10.028
关键词:
摘要: Evaluation of cancer genomes in global context is great interest light changing ethnic distribution the world population. We focused our study on men African ancestry because their disproportionately higher rate prostate (CaP) incidence and mortality. present a systematic whole genome analyses, revealing alterations that differentiate American (AA) Caucasian (CA) CaP genomes. discovered recurrent deletion chromosome 3q13.31 centering LSAMP locus was prevalent tumors from AA (cumulative analyses 435 patients: sequence, 14; FISH evaluations, 101; SNP array, 320 patients). Notably, carriers this experienced more rapid disease progression. In contrast, PTEN ERG common driver were significantly lower compared to CA. Moreover, frequency inter-chromosomal rearrangements than CA tumors. These findings reveal differentially distributed somatic mutations across ancestral groups, which have implications for precision medicine strategies.
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