Exploring Internal Ribosome Entry Sites as Therapeutic Targets.

摘要: Initiation of eukaryotic mRNA translation may proceed via several different routes, each requiring a subset factors and relying on specific interactions between the ribosome. Two modes predominate: (i) so-called cap-dependent initiation, which requires all canonical initiation is responsible for about 95-97% events in cells; (ii) cap-independent internal reduced accounts up to 5% remaining events. Internal relies presence ribosome entry site (IRES) elements 5' UTRs some viral cellular mRNAs. These (often possessing complex secondary tertiary structures) promote efficient interaction with 40S allow entry. mRNAs contribute development severe disease pathological states, such as hepatitis C cancer. Therefore, this mechanism represents an attractive target pharmacological modulation. The purpose review provide insight into current strategies used IRESs discuss physiological consequences (and potential therapeutic implications) abrogation/modulation IRES-mediated translation.