Anaplastic lymphoma kinase and leukocyte tyrosine kinase: functions and genetic interactions in learning, memory and adult neurogenesis.
作者： Joseph B. Weiss , Changhui Xue , Ted Benice , Liquan Xue , Stephan W. Morris
DOI: 10.1016/J.PBB.2011.10.024
关键词:
摘要: Anaplastic Lymphoma Kinase (Alk) is a receptor tyrosine kinase expressed throughout the adult mammalian hippocampus. Recent studies in Drosophila and prior Caenorhabditis elegans have implicated Alk signaling learning neurogenesis. We studied roles of closely related Leukocyte Tyrosine (Ltk) learning, behavior In hippocampus, both receptors are dentate gyrus, CA1 CA3. To assess functional Ltk brain, we analyzed phenotypes mutant, mutant Alk/Ltk double-mutant mice compared to wild-type littermates. Similar Drosophila, found enhanced performance spatial memory mice. Also similar observed reduced neurogenesis associated with loss function. also report genetic interactions between respect behavioral measures such as activity, anxiety levels, retention memory.
elsevier.com
sci-hub.se 参考文章(28)
Joseph B. Weiss, Kaye L. Suyama, Hsiu-Hsiang Lee, Matthew P. Scott, Jelly belly: a Drosophila LDL receptor repeat-containing signal required for mesoderm migration and differentiation. Cell. ,vol. 107, pp. 387- 398 ,(2001) , 10.1016/S0092-8674(01)00540-2
A. Bernards, S. M. de la Monte, The ltk receptor tyrosine kinase is expressed in pre-B lymphocytes and cerebral neurons and uses a non-AUG translational initiator. The EMBO Journal. ,vol. 9, pp. 2279- 2287 ,(1990) , 10.1002/J.1460-2075.1990.TB07399.X
Camilla Englund, Christina E. Lorén, Caroline Grabbe, Gaurav K. Varshney, Fabienne Deleuil, Bengt Hallberg, Ruth H. Palmer, Jeb signals through the Alk receptor tyrosine kinase to drive visceral muscle fusion Nature. ,vol. 425, pp. 512- 516 ,(2003) , 10.1038/NATURE01950
Amy W. Lasek, Jana Lim, Christopher L. Kliethermes, Karen H. Berger, Geoff Joslyn, Gerry Brush, Liquan Xue, Margaret Robertson, Monica S. Moore, Karen Vranizan, Stephan W. Morris, Marc A. Schuckit, Raymond L. White, Ulrike Heberlein, An Evolutionary Conserved Role for Anaplastic Lymphoma Kinase in Behavioral Responses to Ethanol PLoS ONE. ,vol. 6, pp. e22636- ,(2011) , 10.1371/JOURNAL.PONE.0022636
Shawn P. Hurley, Douglas O. Clary, Valerie Copie, Frances Lefcort, Anaplastic lymphoma kinase is dynamically expressed on subsets of motor neurons and in the peripheral nervous system. The Journal of Comparative Neurology. ,vol. 495, pp. 202- 212 ,(2006) , 10.1002/CNE.20887
Yaël P Mossé, Marci Laudenslager, Luca Longo, Kristina A Cole, Andrew Wood, Edward F Attiyeh, Michael J Laquaglia, Rachel Sennett, Jill E Lynch, Patrizia Perri, Geneviève Laureys, Frank Speleman, Cecilia Kim, Cuiping Hou, Hakon Hakonarson, Ali Torkamani, Nicholas J Schork, Garrett M Brodeur, Gian P Tonini, Eric Rappaport, Marcella Devoto, John M Maris, None, Identification of ALK as a major familial neuroblastoma predisposition gene Nature. ,vol. 455, pp. 930- 935 ,(2008) , 10.1038/NATURE07261
Eleni Bazigou, Holger Apitz, Jana Johansson, Christina E. Lorén, Elizabeth M.A. Hirst, Pei-Ling Chen, Ruth H. Palmer, Iris Salecker, Anterograde Jelly belly and Alk Receptor Tyrosine Kinase Signaling Mediates Retinal Axon Targeting in Drosophila Cell. ,vol. 128, pp. 961- 975 ,(2007) , 10.1016/J.CELL.2007.02.024
Isabelle Janoueix-Lerosey, Delphine Lequin, Laurence Brugières, Agnès Ribeiro, Loïc de Pontual, Valérie Combaret, Virginie Raynal, Alain Puisieux, Gudrun Schleiermacher, Gaëlle Pierron, Dominique Valteau-Couanet, Thierry Frebourg, Jean Michon, Stanislas Lyonnet, Jeanne Amiel, Olivier Delattre, Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma Nature. ,vol. 455, pp. 967- 970 ,(2008) , 10.1038/NATURE07398
Toshinori Iwahara, Jiro Fujimoto, Duanzhi Wen, Rod Cupples, Nathan Bucay, Tsutomu Arakawa, Shigeo Mori, Barry Ratzkin, Tadashi Yamamoto, Molecular Characterization of ALK, a Receptor Tyrosine Kinase Expressed Specifically in the Nervous System Oncogene. ,vol. 14, pp. 439- 449 ,(1997) , 10.1038/SJ.ONC.1200849
J. Rohrbough, K. Broadie, Anterograde Jelly belly ligand to Alk receptor signaling at developing synapses is regulated by Mind the gap. Development. ,vol. 137, pp. 3523- 3533 ,(2010) , 10.1242/DEV.047878