Non-invasive assessment of healing of bacteria infected and uninfected wounds using optical coherence tomography.

摘要: Background/purpose: Bacterial infection is one of the main predisposing factors for delay in wound healing. To facilitate a timely decision correct therapy, it important to accurately monitor morphological changes infected wounds using noninvasive tools. In present study, we have explored use optical coherence tomography (OCT) monitoring healing superficial with Staphylococcus aureus mice under vitro and vivo conditions studied collagen birefringence wounds. Methods: The tape stripping method was used generating skin were S. aureus. For studies, uninfected tissues resected, back scattered intensity during on 2, 4 10th day postinfection polarization-sensitive (PS) OCT images compared histology. Real-time studying kinetics conditions. Results: From PS-OCT images, different phases such as inflammation, reepithelialization remodeling could be identified. edematic regions appeared prominent wounds. Compared wounds, reepithelization delayed significantly These comparable stages observed conditions. Conclusion: imaging can provide rapid assessment associated bacteria-infected thereby aid treatment planning.