Suppression of immune responses by dendritic cells infected with HIV.

摘要: Evidence of human immunodeficiency virus (HIV) replication both in the skin Langerhans' cells AIDS patients (Tschachler et al., 1987) and normal, peripheral blood dendritic (DC) (Patterson & Knight, 1987; Knight Patterson, 1989) suggests that infection these antigen-presenting may contribute to immunosuppression seen AIDS. Support for this hypothesis is now provided by experiments which capacity DC infected vitro present mitogen normal syngeneic lymphocytes was measured. Infecting with HIV before culturing inhibited mitogen-stimulated cell proliferation. Viral DNA detected cultures situ hybridization but, addition, also a small proportion lymphocytes. However, introducing an inhibitor replication, 2',3' dideoxyadenosine, after but lymphocytes, blocked growth In latter proliferation responses were still suppressed. Infection could, therefore, cause AIDS, direct effect on antigen-presentation transfer T cells.