Immunity to malaria and naturally acquired antibodies to the circumsporozoite protein of Plasmodium falciparum.

摘要: Abstract A candidate Plasmodium falciparum sporozoite vaccine, R32tet32, which includes 32 tetrapeptide repeats derived from the circumsporozoite protein of P. falciparum, has been developed on basis hypothesis that antibodies to repeat region this will protect against infection. The results two in vitro assays, precipitation reaction and inhibition invasion into hepatoma cells, are thought indicate protective immunity. We therefore tested serum samples persons living a hyperendemic malarious area Indonesia for R32tet32 their ability produce inhibit cells. prevalence mean titer antibody increased with age subjects, whereas infection community decreased. Only IgG or IgM titers ≥1/800 had ac...