Methods for Prophylactically Preventing, Slowing the Progression of, or Treating Alzheimer's Disease

作者: Matin Michael M , Brewer Hollis Bryan

DOI:

关键词:

摘要: The present specification is directed to systems, apparatus and methods for prophylactically preventing, or treating the progression of, Alzheimer's disease. stabilizing, improving Symptoms related Disease (AD) are treated by monitoring a pathophysiological change indicative of AD in patient, based on monitoring, determining if amyloid plaque perivascular space optionally an extent space, presence treatment protocol patient. includes administering patient high density lipoprotein composition derived from mixing blood fraction with lipid removing agent.

参考文章(6)
Lisa Lynn Shafer, Deepak Ramesh Thakker, Methods and device to neutralize soluble toxic agents in the brain ,(2008)
Isabelle Valade, David Migneault, Abderrahim Bouzide, Daniel Delorme, Benoit Bachand, Sophie Levesque, Xianqi Kong, Stephane Ciblat, Mohamed Atfani, Xinfu Wu, Methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid ,(2007)
Marc Bellotti, H. Bryan Brewer, Adam Paul Conner, Timothy Jon Perlman, Hassibullah Akeefe, Methods and apparatus for creating particle derivatives of hdl with reduced lipid content ,(2004)
Cheryl A. Hawkes, Patrick M. Sullivan, Sarah Hands, Roy O. Weller, James A. R. Nicoll, Roxana O. Carare, Disruption of Arterial Perivascular Drainage of Amyloid-β from the Brains of Mice Expressing the Human APOE ε4 Allele PLoS ONE. ,vol. 7, pp. e41636- ,(2012) , 10.1371/JOURNAL.PONE.0041636
Alex E Roher, Yu-Min Kuo, Chera Esh, Carmen Knebel, Nicole Weiss, Walter Kalback, Dean C Luehrs, Jennifer L Childress, Thomas G Beach, Roy O. Weller, Tyler A Kokjohn, Cortical and leptomeningeal cerebrovascular amyloid and white matter pathology in Alzheimer's disease. Molecular Medicine. ,vol. 9, pp. 112- 122 ,(2003) , 10.1007/BF03402043